Fact-sheet: Surfactant deficient disease
Updated on 06/30/2020 at 9:19 AM
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Definition
Anatomically characterized by the presence of hyaline membranes, acidophilic substances lining the distal airways, and especially by diffuse alveolar atelectasis with distension of the alveolar ducts and destruction of the alveolar lining cells
Clinical features
Early respiratory distress Progressive increase in respiratory rate Steady worsening of significant signs of respiratory distress on inspiration combined with expiratory grunting (Silverman score)
Radiography
Severe form: reduced lung volume, diffuse and symmetric opacification of both lung fields obscuring the diaphragmatic contours and mediastinal borders, within which a clear air bronchogram is present.
