Fact-sheet: Lymphoma of orbit
Updated on 09/17/2021 at 12:16 PM
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Definition
Non-Hodgkin malignant lymphoma (NHL) is defined as a malignant proliferation arising from lymphocytes and originating in the various lymphoid structures of the human body. Orbital involvement by NHL is relatively rare and difficult to diagnose.
NHL accounts for 5 to 10% of orbital tumors.
Clinical features
Orbital involvement by NHL frequently occurs in elderly patients around 60 years of age.
Variable clinical manifestations:
- conjunctival or orbital mass
- exophthalmos
- binocular diplopia
- chemosis
- conjunctival hyperemia
- ptosis
- ectropion
CT
Fairly homogeneous soft tissue mass with moderate enhancement after contrast administration
MRI
Orbital protocol:
- Axial and coronal slices
- T1, T2, and T1 FatSat weighting after gadolinium injection
Management
The examination for definitive diagnosis remains biopsy with pathologic examination, more or less accompanied by immunohistochemical or even genetic studies.
Differential diagnosis
inflammatory pseudotumor
