Fact-sheet: Amyloïdosis - Chest


Updated on 07/01/2020 at 9:00 AM

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Definition

Disease of unknown etiology.

It is characterized by extracellular tissue deposition of amyloid substance made of fibrillar proteins.

CT

Respiratory amyloidosis can present in three main and characteristic forms:

  • Tracheobronchial
  • Nodular
  • Diffuse pulmonary

Tracheobronchial involvement is the most common. It presents as nodular deposits or diffuse submucosal infiltration.

Nodular amyloidosis: nodules may be solitary or, more commonly, multiple. They can measure 0.5 to 15 cm in diameter. They generally have well-defined margins. They are often round but may be oval or lobulated. Calcifications or ossifications are occasionally seen.

Diffuse pulmonary amyloidosis: septal linear opacities and reticular opacities, micronodules, and confluent alveolar-type opacities. These opacities may contain small foci of calcification.