Fact-sheet: Pancreatic fistula
Updated on 10/15/2026 at 3:43 PM
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Definition
Early complication of pancreaticoduodenectomy for cancer of the head of the Pancreas, often occurring at the end of the first postoperative week.
Clinical features
Amylase-rich collection draining through the surgical drain.
CT
Low-density, sometimes heterogeneous formation (particularly in cases of superinfection or associated hemorrhage), often poorly defined and in contact with the pancreatic anastomosis
Management
Inhibition of pancreatic secretion with a somatostatin analog and drainage in contact with the fistula, either surgically or percutaneously.