Fact-sheet: Splenic lymphoma
Updated on 09/05/2018 at 4:18 PM
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Definition
Most common malignant tumor of the Spleen, derived from lymphocytic cells.
Clinical features
Mean age: 60 years
Male predominance
Symptoms:
- General deterioration and weight loss
- Fever,
- Malaise, sweats
- Splenomegaly. Splenic involvement may be isolated.
- The presence of lymph node involvement or involvement of another organ (Kidney, liver, or Pancreas) is highly suggestive.
Laboratory findings
Normal
Ultrasound
Hypoechoic splenomegaly.
One or more infiltrating, poorly defined lesions
Splenic involvement by lymphoma may manifest as multiple focal lesions in the form of often hypoechoic nodules of variable size.
CT
- one or more hypodense infiltrating nodular lesions (15 HU)
- or homogeneous splenomegaly
- poor enhancement after injection
Extension: splenic hilar or retroperitoneal lymphadenopathy
MRI
Splenomegaly
T1 and T2 signal close to that of normal Spleen if infiltrative form
Management
Chemotherapy
Radiation
Surgery if isolated lesion
Prognosis: good if early stage
Differential diagnosis
Splenic metastases
