Fact-sheet: Lymphoma of bone
Updated on 09/17/2021 at 12:16 PM
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Definition
Lymphoma of bone may be primary or represent a secondary osseous localization of a diffuse lymphoma.
Clinical features
Pain with an inflammatory pattern,
swelling,
pathologic fracture,
possible medullary or radicular signs in cases of epidural or foraminal involvement
Radiography
Most often, permeative osteolysis, less commonly geographic.
Standard radiographs are sometimes normal.
Osteosclerosis and periosteal reaction are rare.
Beware of osseous localizations of Hodgkin's disease, which can be sclerotic (ivory vertebra)
CT
Less sensitive than MRI and PET-CT.
Lesion originating in the bone marrow with frequent epidural extension and extension into the surrounding soft tissues
MRI
Low T1 signal,
high T2 and STIR signal.
Areas of low T2 signal correspond to tumoral fibrosis.
Contrast enhancement after IV gadolinium injection.
Assessment of extension into the surrounding soft tissues
Nuclear medicine
PET-CT: Highly sensitive and performs staging
