Fact-sheet: HELLP syndrome
Updated on 04/20/2018 at 5:35 PM
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Definition
HELLP SYNDROME, acronym for:
- Hemolysis
- Elevated Liver enzymes
- Low Platelet count
Clinical features
Found in pregnant women in the setting of:
- Preeclampsia
- 5 to 10% of preeclamptic pregnancies
Frequently associated with DIC.
Recurrence: 25%
Laboratory findings
Laboratory findings:
- Elevated AST-ALT and LDH
- Thrombocytopenia
- Low bloog glucose Hypoglycemia
Histology:
- Periportal necrosis
- Fibrin deposits within the hepatic sinusoids
Ultrasound
Heterogeneous hepatic areas corresponding to subcapsular foci of hepatic infarction.
Heterogeneous biconvex image at the periphery of the liver: subcapsular hematoma.
CT
- Biconvex collection at the periphery of the liver, corresponding to a spontaneously hyperdense subcapsular hematoma.
- Peripheral triangular focus, spontaneously hypodense, without enhancement after contrast injection: focus of hepatic infarction.
- Hemoperitoneum with contrast extravasation into the free peritoneal cavity during injection.
Differential diagnosis
- Unrecognized hepatic trauma
- Hepatic infarction of vascular origin
